I mentioned some sweet, free little programs a few months ago. Well, TrueCrypt was updated today, and now offers whole disc encryption, so you get a password prompt when you are booting up. Nice. Plus, OSX and Linux versions. Get it here.
Next, in the same post I mentioned FolderShare, the super awesome automatically syncing software. Well, if you want to pay for a slightly more polished offering, GottaBeMobile mentions that BeInSync is the way to go. (While I love their site, the videos are so mind-numbingly drab and boring, I will never download another media clip from them.) Use at your own risk, though. The comments seem to indicate some problems.